The results of Research Innovation activities should be reproducible. A Scoping Report on the Reproducibility of scientific results in the EU was published in December 2020. 2.2 Sample size refers to the number of patients / test specimens that finish the study and not the number that entered it. When determining sample size, most researchers would want to keep this number as low as possible for reasons of practicality, material costs, time, and availability of facilities to visit and patients. However, the lower limit will also depend on the estimated variation between subjects. Where there is great variation, a larger sample number will be needed. Statistical analysis always takes into consideration the sample size. As Joseph Stalin put it, "A single death is a tragedy; a million deaths is a statistic."5